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A model-based optimization strategy to achieve fast and robust freeze-drying cycles
Freeze-drying is a time and cost-intensive process. The primary drying phase is the main target in a process optimization exercise. Biopharmaceuticals require an amorphous matrix for stabilization, which may collapse during primary drying if the critical temperature of the formulation is exceeded. T...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133743/ https://www.ncbi.nlm.nih.gov/pubmed/37125084 http://dx.doi.org/10.1016/j.ijpx.2023.100180 |