Cargando…

Pathological bile acid concentrations in chronic cholestasis cause adipose mitochondrial defects

BACKGROUND & AIMS: Although fat loss is observed in patients with cholestasis, how chronically elevated bile acids (BAs) impact white and brown fat depots remains obscure. METHODS: To determine the direct effect of pathological levels of BAs on lipid accumulation and mitochondrial function, prim...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Weinan, VanDuyne, Philip, Zhang, Chi, Liu, Yushan, Riessen, Ryan, Barragan, Maribel, Rowitz, Blair M., Teran-Garcia, Margarita, Boppart, Stephen A., Anakk, Sayeepriyadarshini
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10133756/ https://www.ncbi.nlm.nih.gov/pubmed/37122689 http://dx.doi.org/10.1016/j.jhepr.2023.100714

Ejemplares similares

Rebuttal to: The Benevolent Bile: Bile Acids as Stimulants of Liver Regeneration
por: Zhou, Weinan, et al.
Publicado: (2022)

Melancholé: The Dark Side of Bile Acids and Its Cellular Consequences
por: Zhou, Weinan, et al.
Publicado: (2022)

OR23-1 FXR Regulates the Expansion and Metabolic Function of Adipose Tissue upon Caloric Excess
por: Akinrotimi, Oludemilade, et al.
Publicado: (2022)

Constitutive Androstane Receptor Differentially Regulates Bile Acid Homeostasis in Mouse Models of Intrahepatic Cholestasis
por: Kim, Kang Ho, et al.
Publicado: (2018)

PMON295 Investigating the ileal FXR/SHP axis in regulating lipid absorption and enterohepatic recirculation of bile acids
por: Nguyen, James, et al.
Publicado: (2022)

Bile Acids Induce IQ Containing GTPase Activating Protein 1 to Alleviate Liver Injury
por: Sen, Anushna, et al.
Publicado: (2021)

SAT018 Investigate If Sex Differences In Microbiota Is Sufficient To Promote Bile Acid-Mediated Hepatocellular Carcinoma In Mice
por: Dean, Angela E, et al.
Publicado: (2023)

SAT007 Excess Bile Acids Can Compensate To Promote Regeneration In Constitutive Androstane Receptor Knockout Mice
por: Zhou, Weinan, et al.
Publicado: (2023)

RF05 | PSUN357 Scaffold Protein IQGAP1 Bridges Proliferative Signaling Between Bile Acids and the Cellular Microenvironment to Mediate Hepatic Cell Proliferation
por: Anakk, Sayeepriyadarshini, et al.
Publicado: (2022)

Xenobiotic Nuclear Receptor Signaling Determines Molecular Pathogenesis of Progressive Familial Intrahepatic Cholestasis
por: Kim, Kang Ho, et al.
Publicado: (2018)

Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis
por: Mathur, Bhoomika, et al.
Publicado: (2020)

SUN-024 Uncovering a Novel Role for Nuclear Receptor Fxr and Shp in Regulating N-Linked Glycosylation
por: Mathur, Bhoomika, et al.
Publicado: (2019)

SAT017 Investigating The Spatial Regulation Mediated By Constitutive Androstane Receptor
por: Asokakumar, Anjana, et al.
Publicado: (2023)

Bile Acids in Intrahepatic Cholestasis of Pregnancy
por: Majsterek, Maciej, et al.
Publicado: (2022)

SAT009 Investigating The Role Of Hepatic Small Heterodimer Partner In Regulating Gallstone Formation
por: Dang, Nathanlown Mun, et al.
Publicado: (2023)

Larger omental adipocytes correlate with greater Fetuin-A reduction following sleeve gastrectomy
por: Robinson, Katie N., et al.
Publicado: (2019)

Investigating the Role Intestinal-Specific FXR and SHP in Regulating Lipid Metabolism in Mice
por: Nguyen, James ThienToan, et al.
Publicado: (2021)

Fetal cardiac dysfunction in intrahepatic cholestasis of pregnancy is associated with elevated serum bile acid concentrations
por: Vasavan, Tharni, et al.
Publicado: (2021)

OR22-01 Sex Differences In Enterohepatic Circulation Mediated By Hepatic FXR And SHP Depletions In Mice
por: Reichardt, Francois, et al.
Publicado: (2023)

Biochemical profile of bile fluid in patients with malignant cholestasis in comparison with cholestasis due to gall stone
por: Taheri, Hassan, et al.
Publicado: (2015)

Cholestasis: exploring the triangular relationship of gut microbiota-bile acid-cholestasis and the potential probiotic strategies
por: Yu, Leilei, et al.
Publicado: (2023)

Transport systems in cholangiocytes: their role in bile formation and cholestasis.
por: Strazzabosco, M.
Publicado: (1997)

Cholestasis‐induced adaptive remodeling of interlobular bile ducts
por: Vartak, Nachiket, et al.
Publicado: (2016)

RF03 | PMON287 Examining the role of Constitutive Androstane Receptor during Imidacloprid exposure
por: Sen, Anushna, et al.
Publicado: (2022)

Depletion of IQ motif-containing GTPase activating protein 2 (IQGAP2) reduces hepatic glycogen and impairs insulin signaling
por: Sen, Anushna, et al.
Publicado: (2023)

Deletion of Constitutive Androstane Receptor Led to Intestinal Alterations and Increased Imidacloprid in Murine Liver
por: Sen, Anushna, et al.
Publicado: (2022)

THU497 Elucidating The Role Of The IQGAP1-YAP Axis In ECM Stiffness-Mediated Hepatocellular Carcinoma Progression
por: Hobbs, Steven E, et al.
Publicado: (2023)

Placental Expression of Bile Acid Transporters in Intrahepatic Cholestasis of Pregnancy
por: Ontsouka, Edgar, et al.
Publicado: (2021)

Bile Microinfarcts in Cholestasis Are Initiated by Rupture of the Apical Hepatocyte Membrane and Cause Shunting of Bile to Sinusoidal Blood
por: Ghallab, Ahmed, et al.
Publicado: (2018)

Molecular regulation of sinusoidal liver bile acid transporters during cholestasis.
por: Gartung, C., et al.
Publicado: (1997)

Protective effect of dehydroandrographolide on obstructive cholestasis in bile duct-ligated mice
por: Weng, Zhiyong, et al.
Publicado: (2017)

Maternal bile acid profile and subtype analysis of intrahepatic cholestasis of pregnancy
por: Shao, Yong, et al.
Publicado: (2021)

Obstetric cholestasis: A case report on rapid bile acid elevation
por: Yang, Jennifer J., et al.
Publicado: (2023)

Investigating the Role of Farnesoid X Receptor in Heme Biosynthesis and Ductular Reaction
por: Dean, Angela E, et al.
Publicado: (2021)

Hepatic farnesoid X receptor is necessary to facilitate ductular reaction and expression of heme biosynthetic genes
por: Dean, Angela E., et al.
Publicado: (2023)

Omega-3 Polyunsaturated Fatty Acid for Cholestasis due to Bile Duct Paucity
por: Bae, Sun Hwan, et al.
Publicado: (2014)

Cholestasis progression effects on long-term memory in bile duct ligation rats
por: Hosseini, Nasrin, et al.
Publicado: (2014)

Intrahepatic Cholestasis of Pregnancy and Serum Bile Acids in HIV-Infected Pregnant Women
por: Weinberg, Adriana, et al.
Publicado: (2015)

Effect of Bile Acid on Fetal Lung in Rat Model of Intrahepatic Cholestasis of Pregnancy
por: Yu, Ling, et al.
Publicado: (2014)

Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice
por: Cabrera-Rubio, Raul, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_n43vemipfvksqskeemg0ec6781