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Modifications outside CDR1, 2 and 3 of the TCR variable β domain increase TCR expression and antigen-specific function
T cell receptor (TCR) gene modified T cells are a promising form of adoptive cellular therapy against human malignancies and viral infections. Since the first human clinical trial was carried out in 2006, several strategies have been developed to improve the efficacy and safety of TCR engineered T c...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134071/ https://www.ncbi.nlm.nih.gov/pubmed/37122739 http://dx.doi.org/10.3389/fimmu.2023.1148890 |