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Assessment of anti-HIV-1 guide RNA efficacy in cells containing the viral target sequence, corresponding gRNA, and CRISPR/Cas9

The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 gene editing system has been shown to be effective at inhibiting human immunodeficiency virus type 1 (HIV-1). Studies have not consistently used a trackable dual reporter system to determine what cells received the Cas9/gRNA...

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Detalles Bibliográficos
Autores principales: Allen, Alexander G., Chung, Cheng-Han, Worrell, Stephen D., Nwaozo, Glad, Madrid, Rebekah, Mele, Anthony R., Dampier, Will, Nonnemacher, Michael R., Wigdahl, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134072/
https://www.ncbi.nlm.nih.gov/pubmed/37124096
http://dx.doi.org/10.3389/fgeed.2023.1101483