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Poor association between dihydropyrimidine dehydrogenase ( DPYD ) genotype and fluoropyrimidine‐induced toxicity in an Asian population
OBJECTIVE: Dihydropyrimidine dehydrogenase (DPYD) genotype is closely associated with fluoropyrimidine (FP)‐induced toxicities in Caucasian population and European Medicines Agency now recommends DPYD genotype‐based FP dosing strategy. PATIENTS AND METHODS: The current study aimed to investigate the...
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
John Wiley and Sons Inc.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134304/ https://www.ncbi.nlm.nih.gov/pubmed/36524458 http://dx.doi.org/10.1002/cam4.5541 |
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| author | Kanai, Masashi Kawaguchi, Takahisa Kotaka, Masahito Manaka, Dai Hasegawa, Junichi Takagane, Akinori Munemoto, Yoshinori Kato, Takeshi Eto, Tetsuya Touyama, Tetsuo Matsui, Takanori Shinozaki, Katsunori Matsumoto, Shigemi Mizushima, Tsunekazu Mori, Masaki Sakamoto, Junichi Ohtsu, Atsushi Yoshino, Takayuki Saji, Shigetoyo Matsuda, Fumihiko |
| author_facet | Kanai, Masashi Kawaguchi, Takahisa Kotaka, Masahito Manaka, Dai Hasegawa, Junichi Takagane, Akinori Munemoto, Yoshinori Kato, Takeshi Eto, Tetsuya Touyama, Tetsuo Matsui, Takanori Shinozaki, Katsunori Matsumoto, Shigemi Mizushima, Tsunekazu Mori, Masaki Sakamoto, Junichi Ohtsu, Atsushi Yoshino, Takayuki Saji, Shigetoyo Matsuda, Fumihiko |
| author_sort | Kanai, Masashi |
| collection | PubMed |
| description | OBJECTIVE: Dihydropyrimidine dehydrogenase (DPYD) genotype is closely associated with fluoropyrimidine (FP)‐induced toxicities in Caucasian population and European Medicines Agency now recommends DPYD genotype‐based FP dosing strategy. PATIENTS AND METHODS: The current study aimed to investigate their impact on FP‐related toxicities in an Asian population using genome‐wide association study (GWAS) data set from 1364 patients with colon cancer. RESULTS: Among 82 variants registered in the Clinical Pharmacogenetics Implementation Consortium, 74 DPYD variants were directly genotyped in GWAS cohort; however, only 7 nonsynonymous DPYD variants (CPIC variants) were identified and none of the four recurrent DPYD variants (DPYD*2A, c.2846A>T, c.1679T>G, c.1236G>A) were included. Seven CPIC variants were investigated for their association with the incidence of FP‐related toxicities; however, none of these variants revealed a significant correlation with FP‐related toxicities. CONCLUSION: These data suggested that the DPYD genotype registered in CPIC plays a minor role in FP‐related toxicities in an Asian population. |
| format | Online Article Text |
| id | pubmed-10134304 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2022 |
| publisher | John Wiley and Sons Inc. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-101343042023-04-28 Poor association between dihydropyrimidine dehydrogenase ( DPYD ) genotype and fluoropyrimidine‐induced toxicity in an Asian population Kanai, Masashi Kawaguchi, Takahisa Kotaka, Masahito Manaka, Dai Hasegawa, Junichi Takagane, Akinori Munemoto, Yoshinori Kato, Takeshi Eto, Tetsuya Touyama, Tetsuo Matsui, Takanori Shinozaki, Katsunori Matsumoto, Shigemi Mizushima, Tsunekazu Mori, Masaki Sakamoto, Junichi Ohtsu, Atsushi Yoshino, Takayuki Saji, Shigetoyo Matsuda, Fumihiko Cancer Med BRIEF COMMUNICATION OBJECTIVE: Dihydropyrimidine dehydrogenase (DPYD) genotype is closely associated with fluoropyrimidine (FP)‐induced toxicities in Caucasian population and European Medicines Agency now recommends DPYD genotype‐based FP dosing strategy. PATIENTS AND METHODS: The current study aimed to investigate their impact on FP‐related toxicities in an Asian population using genome‐wide association study (GWAS) data set from 1364 patients with colon cancer. RESULTS: Among 82 variants registered in the Clinical Pharmacogenetics Implementation Consortium, 74 DPYD variants were directly genotyped in GWAS cohort; however, only 7 nonsynonymous DPYD variants (CPIC variants) were identified and none of the four recurrent DPYD variants (DPYD*2A, c.2846A>T, c.1679T>G, c.1236G>A) were included. Seven CPIC variants were investigated for their association with the incidence of FP‐related toxicities; however, none of these variants revealed a significant correlation with FP‐related toxicities. CONCLUSION: These data suggested that the DPYD genotype registered in CPIC plays a minor role in FP‐related toxicities in an Asian population. John Wiley and Sons Inc. 2022-12-16 /pmc/articles/PMC10134304/ /pubmed/36524458 http://dx.doi.org/10.1002/cam4.5541 Text en © 2022 The Authors. Cancer Medicine published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | BRIEF COMMUNICATION Kanai, Masashi Kawaguchi, Takahisa Kotaka, Masahito Manaka, Dai Hasegawa, Junichi Takagane, Akinori Munemoto, Yoshinori Kato, Takeshi Eto, Tetsuya Touyama, Tetsuo Matsui, Takanori Shinozaki, Katsunori Matsumoto, Shigemi Mizushima, Tsunekazu Mori, Masaki Sakamoto, Junichi Ohtsu, Atsushi Yoshino, Takayuki Saji, Shigetoyo Matsuda, Fumihiko Poor association between dihydropyrimidine dehydrogenase ( DPYD ) genotype and fluoropyrimidine‐induced toxicity in an Asian population |
| title | Poor association between dihydropyrimidine dehydrogenase (
DPYD
) genotype and fluoropyrimidine‐induced toxicity in an Asian population |
| title_full | Poor association between dihydropyrimidine dehydrogenase (
DPYD
) genotype and fluoropyrimidine‐induced toxicity in an Asian population |
| title_fullStr | Poor association between dihydropyrimidine dehydrogenase (
DPYD
) genotype and fluoropyrimidine‐induced toxicity in an Asian population |
| title_full_unstemmed | Poor association between dihydropyrimidine dehydrogenase (
DPYD
) genotype and fluoropyrimidine‐induced toxicity in an Asian population |
| title_short | Poor association between dihydropyrimidine dehydrogenase (
DPYD
) genotype and fluoropyrimidine‐induced toxicity in an Asian population |
| title_sort | poor association between dihydropyrimidine dehydrogenase (
dpyd
) genotype and fluoropyrimidine‐induced toxicity in an asian population |
| topic | BRIEF COMMUNICATION |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134304/ https://www.ncbi.nlm.nih.gov/pubmed/36524458 http://dx.doi.org/10.1002/cam4.5541 |
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