Molecular Mechanisms of Functional Modulation of Transcriptional Coactivator PC4 via Phosphorylation on Its Intrinsically Disordered Region

[Image: see text] To investigate the effects of phosphorylation on the function of the human positive cofactor 4 (PC4), an enhanced molecular dynamics (MD) simulation was performed. The simulation system consists of the N-terminal intrinsic disordered region (IDR) of PC4 and a complex that comprises...

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Detalles Bibliográficos
Autores principales: Xie, Qilin, Kasahara, Kota, Higo, Junichi, Takahashi, Takuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134458/
https://www.ncbi.nlm.nih.gov/pubmed/37125110
http://dx.doi.org/10.1021/acsomega.3c00364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10134458/
https://www.ncbi.nlm.nih.gov/pubmed/37125110
http://dx.doi.org/10.1021/acsomega.3c00364

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