Molecular Modification of Kex2 P1’ Site Enhances Expression and Druggability of Fungal Defensin

Pichia pastoris is the widely used expression system for producing recombinant secretory proteins. It is known that Kex2 protease plays a vital role in the process of protein secretion, in which the P1’ site affects its cleavage efficiency. To enhance the expression level of fungal defensin-derived...

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Detalles Bibliográficos
Autores principales: Jin, Yanjie, Yang, Na, Teng, Da, Hao, Ya, Mao, Ruoyu, Wang, Jianhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135057/
https://www.ncbi.nlm.nih.gov/pubmed/37107149
http://dx.doi.org/10.3390/antibiotics12040786

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135057/
https://www.ncbi.nlm.nih.gov/pubmed/37107149
http://dx.doi.org/10.3390/antibiotics12040786

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