Kaurane-Type Diterpenoids as Potential Inhibitors of Dihydrofolate Reductase-Thymidylate Synthase in New World Leishmania Species

The bifunctional enzyme Dihydrofolate reductase-thymidylate synthase (DHFR-TS) plays a crucial role in the survival of the Leishmania parasite, as folates are essential cofactors for purine and pyrimidine nucleotide biosynthesis. However, DHFR inhibitors are largely ineffective in controlling trypan...

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Detalles Bibliográficos
Autores principales: Herrera-Acevedo, Chonny, de Menezes, Renata Priscila Barros, de Sousa, Natália Ferreira, Scotti, Luciana, Scotti, Marcus Tullius, Coy-Barrera, Ericsson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135059/
https://www.ncbi.nlm.nih.gov/pubmed/37107025
http://dx.doi.org/10.3390/antibiotics12040663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135059/
https://www.ncbi.nlm.nih.gov/pubmed/37107025
http://dx.doi.org/10.3390/antibiotics12040663

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