Effect of Prior Antibiotic Use on Culture Results in People with Diabetes and Foot Osteomyelitis

Background: Antibiotic use prior to biopsy acquisition in people with diabetes and osteomyelitis of the foot (DFO) might influence bacterial yield in cultures or induce bacterial resistance. Obtaining reliable culture results is pivotal to guide antibiotics for conservative treatment of DFO. Methods...

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Autores principales: Gramberg, Meryl Cinzía Tila Tamara, Van Hattem, Jarne Marijn, Dijkstra, Jacob Albert, Dros, Emma, Nieuwdorp, Max, Sabelis, Louise Willy Elizabeth, Peters, Edgar Josephus Gerardus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135220/
https://www.ncbi.nlm.nih.gov/pubmed/37107046
http://dx.doi.org/10.3390/antibiotics12040684
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author Gramberg, Meryl Cinzía Tila Tamara
Van Hattem, Jarne Marijn
Dijkstra, Jacob Albert
Dros, Emma
Nieuwdorp, Max
Sabelis, Louise Willy Elizabeth
Peters, Edgar Josephus Gerardus
author_facet Gramberg, Meryl Cinzía Tila Tamara
Van Hattem, Jarne Marijn
Dijkstra, Jacob Albert
Dros, Emma
Nieuwdorp, Max
Sabelis, Louise Willy Elizabeth
Peters, Edgar Josephus Gerardus
author_sort Gramberg, Meryl Cinzía Tila Tamara
collection PubMed
description Background: Antibiotic use prior to biopsy acquisition in people with diabetes and osteomyelitis of the foot (DFO) might influence bacterial yield in cultures or induce bacterial resistance. Obtaining reliable culture results is pivotal to guide antibiotics for conservative treatment of DFO. Methods: We prospectively analysed cultures of ulcer bed and percutaneous bone biopsies of people with DFO and investigated if antibiotics administered prior to (<2 months up to 7 days) biopsy acquisition led to more negative cultures or increased resistance in virulent bacteria. We calculated relative risks (RR) and 95% confidence intervals (CIs). We stratified analyses according to biopsy type (ulcer bed or bone). Results: We analysed bone and ulcer bed biopsies of 64 people, of whom 29 received prior antibiotics, and found that prior antibiotics did not lead to a higher risk of at least one negative culture (RR 1.3, (CI 0.8–2.0), nor did prior treatment increase the risk of a specific type of negative culture (RR for bone cultures 1.15, (CI 0.75–1.7), RR for ulcer bed cultures 0.92 (CI 0.33–2.6)) or both cultures (RR 1.3 (CI 0.35–4.7), and neither did it increase the risk of antibiotic resistance in the combined bacterial results of ulcer bed and bone cultures (RR 0.64, (CI 0.23–1.8)). Conclusions: Antibiotics administered up to 7 days before obtaining biopsies in people with DFO do not influence culture yield regardless of biopsy type, nor are they associated with more antibiotic resistance.
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spelling pubmed-101352202023-04-28 Effect of Prior Antibiotic Use on Culture Results in People with Diabetes and Foot Osteomyelitis Gramberg, Meryl Cinzía Tila Tamara Van Hattem, Jarne Marijn Dijkstra, Jacob Albert Dros, Emma Nieuwdorp, Max Sabelis, Louise Willy Elizabeth Peters, Edgar Josephus Gerardus Antibiotics (Basel) Article Background: Antibiotic use prior to biopsy acquisition in people with diabetes and osteomyelitis of the foot (DFO) might influence bacterial yield in cultures or induce bacterial resistance. Obtaining reliable culture results is pivotal to guide antibiotics for conservative treatment of DFO. Methods: We prospectively analysed cultures of ulcer bed and percutaneous bone biopsies of people with DFO and investigated if antibiotics administered prior to (<2 months up to 7 days) biopsy acquisition led to more negative cultures or increased resistance in virulent bacteria. We calculated relative risks (RR) and 95% confidence intervals (CIs). We stratified analyses according to biopsy type (ulcer bed or bone). Results: We analysed bone and ulcer bed biopsies of 64 people, of whom 29 received prior antibiotics, and found that prior antibiotics did not lead to a higher risk of at least one negative culture (RR 1.3, (CI 0.8–2.0), nor did prior treatment increase the risk of a specific type of negative culture (RR for bone cultures 1.15, (CI 0.75–1.7), RR for ulcer bed cultures 0.92 (CI 0.33–2.6)) or both cultures (RR 1.3 (CI 0.35–4.7), and neither did it increase the risk of antibiotic resistance in the combined bacterial results of ulcer bed and bone cultures (RR 0.64, (CI 0.23–1.8)). Conclusions: Antibiotics administered up to 7 days before obtaining biopsies in people with DFO do not influence culture yield regardless of biopsy type, nor are they associated with more antibiotic resistance. MDPI 2023-03-31 /pmc/articles/PMC10135220/ /pubmed/37107046 http://dx.doi.org/10.3390/antibiotics12040684 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gramberg, Meryl Cinzía Tila Tamara
Van Hattem, Jarne Marijn
Dijkstra, Jacob Albert
Dros, Emma
Nieuwdorp, Max
Sabelis, Louise Willy Elizabeth
Peters, Edgar Josephus Gerardus
Effect of Prior Antibiotic Use on Culture Results in People with Diabetes and Foot Osteomyelitis
title Effect of Prior Antibiotic Use on Culture Results in People with Diabetes and Foot Osteomyelitis
title_full Effect of Prior Antibiotic Use on Culture Results in People with Diabetes and Foot Osteomyelitis
title_fullStr Effect of Prior Antibiotic Use on Culture Results in People with Diabetes and Foot Osteomyelitis
title_full_unstemmed Effect of Prior Antibiotic Use on Culture Results in People with Diabetes and Foot Osteomyelitis
title_short Effect of Prior Antibiotic Use on Culture Results in People with Diabetes and Foot Osteomyelitis
title_sort effect of prior antibiotic use on culture results in people with diabetes and foot osteomyelitis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135220/
https://www.ncbi.nlm.nih.gov/pubmed/37107046
http://dx.doi.org/10.3390/antibiotics12040684
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