Synthesis, Molecular Docking Study, and Biological Evaluation of New 4-(2,5-Dimethyl-1H-pyrrol-1-yl)-N’-(2-(substituted)acetyl)benzohydrazides as Dual Enoyl ACP Reductase and DHFR Enzyme Inhibitors

In this study, a new series of 4-(2,5-dimethyl-1H-pyrrol-1-yl)-N′-(2-(substituted)acetyl) benzohydrazides (5a–n) were prepared and new heterocycles underwent thorough characterization and evaluation for antibacterial activity; some of them underwent further testing for in vitro inhibition of enoyl A...

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Detalles Bibliográficos
Autores principales: Mahnashi, Mater H., Koganole, Pooja, S. R., Prem Kumar, Ashgar, Sami S., Shaikh, Ibrahim Ahmed, Joshi, Shrinivas D., Alqahtani, Ali S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135272/
https://www.ncbi.nlm.nih.gov/pubmed/37107123
http://dx.doi.org/10.3390/antibiotics12040763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135272/
https://www.ncbi.nlm.nih.gov/pubmed/37107123
http://dx.doi.org/10.3390/antibiotics12040763

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