A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery

In prokaryotes, translation can occur on mRNA that is being transcribed in a process called coupling. How the ribosome affects the RNA polymerase (RNAP) during coupling is not well understood. Here, we reconstituted the E. coli coupling system and demonstrated that the ribosome can prevent pausing a...

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Detalles Bibliográficos
Autores principales: Wee, Liang Meng, Tong, Alexander B., Ariza, Alfredo Jose Florez, Cañari-Chumpitaz, Cristhian, Grob, Patricia, Nogales, Eva, Bustamante, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135430/
https://www.ncbi.nlm.nih.gov/pubmed/36931247
http://dx.doi.org/10.1016/j.cell.2023.02.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135430/
https://www.ncbi.nlm.nih.gov/pubmed/36931247
http://dx.doi.org/10.1016/j.cell.2023.02.008

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