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A trailing ribosome speeds up RNA polymerase at the expense of transcript fidelity via force and allostery
In prokaryotes, translation can occur on mRNA that is being transcribed in a process called coupling. How the ribosome affects the RNA polymerase (RNAP) during coupling is not well understood. Here, we reconstituted the E. coli coupling system and demonstrated that the ribosome can prevent pausing a...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135430/ https://www.ncbi.nlm.nih.gov/pubmed/36931247 http://dx.doi.org/10.1016/j.cell.2023.02.008 |