LRRK2 Structure-Based Activation Mechanism and Pathogenesis

Mutations in the multidomain protein Leucine-rich-repeat kinase 2 (LRRK2) have been identified as a genetic risk factor for both sporadic and familial Parkinson’s disease (PD). LRRK2 has two enzymatic domains: a RocCOR tandem with GTPase activity and a kinase domain. In addition, LRRK2 has three N-t...

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Detalles Bibliográficos
Autores principales: Zhang, Xiaojuan, Kortholt, Arjan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135577/
https://www.ncbi.nlm.nih.gov/pubmed/37189360
http://dx.doi.org/10.3390/biom13040612

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135577/
https://www.ncbi.nlm.nih.gov/pubmed/37189360
http://dx.doi.org/10.3390/biom13040612

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