Small Molecules Targeting Kidney ClC-K Chloride Channels: Applications in Rare Tubulopathies and Common Cardiovascular Diseases

Given the key role played by ClC-K chloride channels in kidney and inner ear physiology and pathology, they can be considered important targets for drug discovery. Indeed, ClC-Ka and ClC-Kb inhibition would interfere with the urine countercurrent concentration mechanism in Henle’s loop, which is res...

Descripción completa

Detalles Bibliográficos
Autores principales: Coppola, Maria Antonietta, Pusch, Michael, Imbrici, Paola, Liantonio, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135884/
https://www.ncbi.nlm.nih.gov/pubmed/37189456
http://dx.doi.org/10.3390/biom13040710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10135884/
https://www.ncbi.nlm.nih.gov/pubmed/37189456
http://dx.doi.org/10.3390/biom13040710

Ejemplares similares