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A Soluble Platelet-Derived Growth Factor Receptor-β Originates via Pre-mRNA Splicing in the Healthy Brain and Is Upregulated during Hypoxia and Aging
The platelet-derived growth factor-BB (PDGF-BB) pathway provides critical regulation of cerebrovascular pericytes, orchestrating their investment and retention within the brain microcirculation. Dysregulated PDGF Receptor-beta (PDGFRβ) signaling can lead to pericyte defects that compromise blood-bra...
Autores principales: | Payne, Laura Beth, Abdelazim, Hanaa, Hoque, Maruf, Barnes, Audra, Mironovova, Zuzana, Willi, Caroline E., Darden, Jordan, Houk, Clifton, Sedovy, Meghan W., Johnstone, Scott R., Chappell, John C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136073/ https://www.ncbi.nlm.nih.gov/pubmed/37189457 http://dx.doi.org/10.3390/biom13040711 |
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