Electronic Circular Dichroism Detects Conformational Changes Associated with Proteasome Gating Confirmed Using AFM Imaging

Many chronic diseases, including cancer and neurodegeneration, are linked to proteasome dysregulation. Proteasome activity, essential for maintaining proteostasis in a cell, is controlled by the gating mechanism and its underlying conformational transitions. Thus, developing effective methods to det...

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Detalles Bibliográficos
Autores principales: D’Urso, Alessandro, Purrello, Roberto, Cunsolo, Alessandra, Milardi, Danilo, Fattorusso, Caterina, Persico, Marco, Gaczynska, Maria, Osmulski, Pawel A., Santoro, Anna Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136135/
https://www.ncbi.nlm.nih.gov/pubmed/37189451
http://dx.doi.org/10.3390/biom13040704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136135/
https://www.ncbi.nlm.nih.gov/pubmed/37189451
http://dx.doi.org/10.3390/biom13040704

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