Bromodomain Protein Inhibitors Reorganize the Chromatin of Synovial Fibroblasts

Bromodomain- and extra-terminal domain (BET) proteins are epigenetic reader proteins that regulate transcription of their target genes by binding to acetylated histone side chains. Small molecule inhibitors, such as I-BET151, have anti-inflammatory properties in fibroblast-like synoviocytes (FLS) an...

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Detalles Bibliográficos
Autores principales: Krošel, Monika, Moser, Larissa, Houtman, Miranda, Friščić, Jasna, Tomšič, Matija, Distler, Oliver, Hoffmann, Markus H., Ospelt, Caroline, Klein, Kerstin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136646/
https://www.ncbi.nlm.nih.gov/pubmed/37190058
http://dx.doi.org/10.3390/cells12081149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136646/
https://www.ncbi.nlm.nih.gov/pubmed/37190058
http://dx.doi.org/10.3390/cells12081149

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