Inducible MLL-AF9 Expression Drives an AML Program during Human Pluripotent Stem Cell-Derived Hematopoietic Differentiation

A t(9;11)(p22;q23) translocation produces the MLL-AF9 fusion protein, which is found in up to 25% of de novo AML cases in children. Despite major advances, obtaining a comprehensive understanding of context-dependent MLL-AF9-mediated gene programs during early hematopoiesis is challenging. Here, we...

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Detalles Bibliográficos
Autores principales: Heuts, Branco M. H., Arza-Apalategi, Saioa, Alkema, Sinne G., Tijchon, Esther, Jussen, Laura, Bergevoet, Saskia M., van der Reijden, Bert A., Martens, Joost H. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136707/
https://www.ncbi.nlm.nih.gov/pubmed/37190104
http://dx.doi.org/10.3390/cells12081195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136707/
https://www.ncbi.nlm.nih.gov/pubmed/37190104
http://dx.doi.org/10.3390/cells12081195

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