The TREM2 H157Y Variant Influences Microglial Phagocytosis, Polarization, and Inflammatory Cytokine Release

Previously, we reported that H157Y, a rare coding variant on exon 3 of the triggering receptor expressed on myeloid cells 2 gene (TREM2), was associated with Alzheimer’s disease (AD) risk in a Han Chinese population. To date, how this variant increases AD risk has remained unclear. In this study, us...

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Detalles Bibliográficos
Autores principales: Fu, Xin-Xin, Chen, Shuai-Yu, Lian, Hui-Wen, Deng, Yang, Duan, Rui, Zhang, Ying-Dong, Jiang, Teng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136710/
https://www.ncbi.nlm.nih.gov/pubmed/37190607
http://dx.doi.org/10.3390/brainsci13040642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136710/
https://www.ncbi.nlm.nih.gov/pubmed/37190607
http://dx.doi.org/10.3390/brainsci13040642

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