FAK Inhibitor-Based Combinations with MEK or PKC Inhibitors Trigger Synergistic Antitumor Effects in Uveal Melanoma

SIMPLE SUMMARY: Uveal Melanoma (UM) is a rare and malignant intraocular tumor with dismal prognosis. Despite efficient control of the primary tumor by radiation or surgery, up to 50% of patients subsequently develop metastases, mainly in the liver. The treatment of UM metastases is challenging and t...

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Detalles Bibliográficos
Autores principales: Tarin, Malcy, Némati, Fariba, Decaudin, Didier, Canbezdi, Christine, Marande, Benjamin, Silva, Lisseth, Derrien, Héloïse, Jochemsen, Aart G., Gardrat, Sophie, Piperno-Neumann, Sophie, Rodrigues, Manuel, Mariani, Pascale, Cassoux, Nathalie, Stern, Marc-Henri, Roman-Roman, Sergio, Alsafadi, Samar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136875/
https://www.ncbi.nlm.nih.gov/pubmed/37190207
http://dx.doi.org/10.3390/cancers15082280

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136875/
https://www.ncbi.nlm.nih.gov/pubmed/37190207
http://dx.doi.org/10.3390/cancers15082280

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