Cargando…
atm Mutation and Oxidative Stress Enhance the Pre-Cancerous Effects of UHRF1 Overexpression in Zebrafish Livers
SIMPLE SUMMARY: Mutation of the ataxia-telangiectasia mutated (atm) gene in humans and mice renders them susceptible to tumors due to both its role as a DNA damage sensor acting in pre-malignant cells to activate Tp53 and to its role in sensing and reducing oxidative stress. The oncogene UHRF1 is ov...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136906/ https://www.ncbi.nlm.nih.gov/pubmed/37190230 http://dx.doi.org/10.3390/cancers15082302 |