atm Mutation and Oxidative Stress Enhance the Pre-Cancerous Effects of UHRF1 Overexpression in Zebrafish Livers

SIMPLE SUMMARY: Mutation of the ataxia-telangiectasia mutated (atm) gene in humans and mice renders them susceptible to tumors due to both its role as a DNA damage sensor acting in pre-malignant cells to activate Tp53 and to its role in sensing and reducing oxidative stress. The oncogene UHRF1 is ov...

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Detalles Bibliográficos
Autores principales: Ajouaou, Yousra, Magnani, Elena, Madakashira, Bhavani, Jenkins, Eleanor, Sadler, Kirsten C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136906/
https://www.ncbi.nlm.nih.gov/pubmed/37190230
http://dx.doi.org/10.3390/cancers15082302

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10136906/
https://www.ncbi.nlm.nih.gov/pubmed/37190230
http://dx.doi.org/10.3390/cancers15082302

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