Partial Inhibition of Complex I Restores Mitochondrial Morphology and Mitochondria-ER Communication in Hippocampus of APP/PS1 Mice

Alzheimer’s disease (AD) has no cure. Earlier, we showed that partial inhibition of mitochondrial complex I (MCI) with the small molecule CP2 induces an adaptive stress response, activating multiple neuroprotective mechanisms. Chronic treatment reduced inflammation, Aβ and pTau accumulation, improve...

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Detalles Bibliográficos
Autores principales: Panes, Jessica, Nguyen, Thi Kim Oanh, Gao, Huanyao, Christensen, Trace A., Stojakovic, Andrea, Trushin, Sergey, Salisbury, Jeffrey L., Fuentealba, Jorge, Trushina, Eugenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10137328/
https://www.ncbi.nlm.nih.gov/pubmed/37190020
http://dx.doi.org/10.3390/cells12081111

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10137328/
https://www.ncbi.nlm.nih.gov/pubmed/37190020
http://dx.doi.org/10.3390/cells12081111

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