Damage-Free Shortening of Telomeres Is a Potential Strategy Supporting Blind Mole-Rat Longevity

Telomere shortening or loss of shelterin components activates DNA damage response (DDR) pathways, leading to a replicative senescence that is usually coupled with a senescence-associated secretory phenotype (SASP). Recent studies suggested that telomere aberration that activates DDR may occur, irres...

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Detalles Bibliográficos
Autores principales: Adwan Shekhidem, Huda, Sharvit, Lital, Huffman, Derek M., Manov, Irena, Atzmon, Gil, Shams, Imad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10137574/
https://www.ncbi.nlm.nih.gov/pubmed/37107603
http://dx.doi.org/10.3390/genes14040845

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10137574/
https://www.ncbi.nlm.nih.gov/pubmed/37107603
http://dx.doi.org/10.3390/genes14040845

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