Selective Hepatic Cbs Knockout Aggravates Liver Damage, Endothelial Dysfunction and ROS Stress in Mice Fed a Western Diet

Cystathionine-β-synthase (CBS) is highly expressed in the liver, and deficiencies in Cbs lead to hyperhomocysteinemia (HHCy) and disturbed production of antioxidants such as hydrogen sulfide. We therefore hypothesized that liver-specific Cbs deficient (LiCKO) mice would be particularly susceptible t...

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Detalles Bibliográficos
Autores principales: Lambooy, Sebastiaan, Heida, Andries, Joschko, Christian, Nakladal, Dalibor, van Buiten, Azuwerus, Kloosterhuis, Niels, Huijkman, Nicolette, Gerding, Albert, van de Sluis, Bart, Henning, Robert, Deelman, Leo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138434/
https://www.ncbi.nlm.nih.gov/pubmed/37108182
http://dx.doi.org/10.3390/ijms24087019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138434/
https://www.ncbi.nlm.nih.gov/pubmed/37108182
http://dx.doi.org/10.3390/ijms24087019

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