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Placental Remote Control of Fetal Metabolism: Trophoblast mTOR Signaling Regulates Liver IGFBP-1 Phosphorylation and IGF-1 Bioavailability
The mechanisms mediating the restricted growth in intrauterine growth restriction (IUGR) remain to be fully established. Mechanistic target of rapamycin (mTOR) signaling functions as a placental nutrient sensor, indirectly influencing fetal growth by regulating placental function. Increased secretio...
Autores principales: | Rosario, Fredrick J., Chopra, Anand, Biggar, Kyle, Powell, Theresa L., Gupta, Madhulika B., Jansson, Thomas |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138459/ https://www.ncbi.nlm.nih.gov/pubmed/37108437 http://dx.doi.org/10.3390/ijms24087273 |
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