Hypoxia Increases ATX Expression by Histone Crotonylation in a HIF-2α-Dependent Manner

Autotaxin (ATX), the key enzyme that generates lysophosphatidic acid (LPA) from lysophosphatidylcholine (LPC), is involved in tumorigenesis through the ATX-LPA axis and is regarded as a valuable target in tumor therapy. Hypoxia is a major feature of solid tumors and contributes to tumor development...

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Detalles Bibliográficos
Autores principales: Qu, Mengxia, Long, Yang, Wang, Yuqin, Yin, Nan, Zhang, Xiaotian, Zhang, Junjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138485/
https://www.ncbi.nlm.nih.gov/pubmed/37108194
http://dx.doi.org/10.3390/ijms24087031

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138485/
https://www.ncbi.nlm.nih.gov/pubmed/37108194
http://dx.doi.org/10.3390/ijms24087031

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