PARP1 Activation Induces HMGB1 Secretion Promoting Intestinal Inflammation in Mice and Human Intestinal Organoids

Extracellular High-mobility group box 1 (HMGB1) contributes to the pathogenesis of inflammatory disorders, including inflammatory bowel diseases (IBD). Poly (ADP-ribose) polymerase 1 (PARP1) has been recently reported to promote HMGB1 acetylation and its secretion outside cells. In this study, the r...

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Detalles Bibliográficos
Autores principales: Vitali, Roberta, Mancuso, Anna Barbara, Palone, Francesca, Pioli, Claudio, Cesi, Vincenzo, Negroni, Anna, Cucchiara, Salvatore, Oliva, Salvatore, Carissimi, Claudia, Laudadio, Ilaria, Stronati, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138503/
https://www.ncbi.nlm.nih.gov/pubmed/37108260
http://dx.doi.org/10.3390/ijms24087096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138503/
https://www.ncbi.nlm.nih.gov/pubmed/37108260
http://dx.doi.org/10.3390/ijms24087096

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