Resistance to TOP-1 Inhibitors: Good Old Drugs Still Can Surprise Us

Irinotecan (SN-38) is a potent and broad-spectrum anticancer drug that targets DNA topoisomerase I (Top1). It exerts its cytotoxic effects by binding to the Top1-DNA complex and preventing the re-ligation of the DNA strand, leading to the formation of lethal DNA breaks. Following the initial respons...

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Detalles Bibliográficos
Autores principales: Kumar, Santosh, Sherman, Michael Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138578/
https://www.ncbi.nlm.nih.gov/pubmed/37108395
http://dx.doi.org/10.3390/ijms24087233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138578/
https://www.ncbi.nlm.nih.gov/pubmed/37108395
http://dx.doi.org/10.3390/ijms24087233

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