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Resistance to TOP-1 Inhibitors: Good Old Drugs Still Can Surprise Us
Irinotecan (SN-38) is a potent and broad-spectrum anticancer drug that targets DNA topoisomerase I (Top1). It exerts its cytotoxic effects by binding to the Top1-DNA complex and preventing the re-ligation of the DNA strand, leading to the formation of lethal DNA breaks. Following the initial respons...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138578/ https://www.ncbi.nlm.nih.gov/pubmed/37108395 http://dx.doi.org/10.3390/ijms24087233 |