NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity

Aggressive tumors evade cytotoxic T lymphocytes by suppressing MHC class-I (MHC-I) expression that also compromises tumor responsiveness to immunotherapy. MHC-I defects strongly correlate to defective expression of NLRC5, the transcriptional activator of MHC-I and antigen processing genes. In poorly...

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Detalles Bibliográficos
Autores principales: Santharam, Madanraj Appiya, Shukla, Akhil, Levesque, Dominique, Kufer, Thomas A., Boisvert, François-Michel, Ramanathan, Sheela, Ilangumaran, Subburaj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138588/
https://www.ncbi.nlm.nih.gov/pubmed/37108368
http://dx.doi.org/10.3390/ijms24087206

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138588/
https://www.ncbi.nlm.nih.gov/pubmed/37108368
http://dx.doi.org/10.3390/ijms24087206

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