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NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity
Aggressive tumors evade cytotoxic T lymphocytes by suppressing MHC class-I (MHC-I) expression that also compromises tumor responsiveness to immunotherapy. MHC-I defects strongly correlate to defective expression of NLRC5, the transcriptional activator of MHC-I and antigen processing genes. In poorly...
Autores principales: | Santharam, Madanraj Appiya, Shukla, Akhil, Levesque, Dominique, Kufer, Thomas A., Boisvert, François-Michel, Ramanathan, Sheela, Ilangumaran, Subburaj |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138588/ https://www.ncbi.nlm.nih.gov/pubmed/37108368 http://dx.doi.org/10.3390/ijms24087206 |
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