Cargando…

NLRC5-CIITA Fusion Protein as an Effective Inducer of MHC-I Expression and Antitumor Immunity

Aggressive tumors evade cytotoxic T lymphocytes by suppressing MHC class-I (MHC-I) expression that also compromises tumor responsiveness to immunotherapy. MHC-I defects strongly correlate to defective expression of NLRC5, the transcriptional activator of MHC-I and antigen processing genes. In poorly...

Descripción completa

Detalles Bibliográficos
Autores principales:	Santharam, Madanraj Appiya, Shukla, Akhil, Levesque, Dominique, Kufer, Thomas A., Boisvert, François-Michel, Ramanathan, Sheela, Ilangumaran, Subburaj
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138588/ https://www.ncbi.nlm.nih.gov/pubmed/37108368 http://dx.doi.org/10.3390/ijms24087206

Ejemplares similares

The MHC Class-I Transactivator NLRC5: Implications to Cancer Immunology and Potential Applications to Cancer Immunotherapy
por: Shukla, Akhil, et al.
Publicado: (2021)

Inflammatory Cytokines That Enhance Antigen Responsiveness of Naïve CD8(+) T Lymphocytes Modulate Chromatin Accessibility of Genes Impacted by Antigen Stimulation
por: Quenum, Akouavi Julite Irmine, et al.
Publicado: (2022)

Prognostic significance of SOCS1 and SOCS3 tumor suppressors and oncogenic signaling pathway genes in hepatocellular carcinoma
por: Khan, Md Gulam Musawwir, et al.
Publicado: (2020)

NLRC5 Deficiency Deregulates Hepatic Inflammatory Response but Does Not Aggravate Carbon Tetrachloride-Induced Liver Fibrosis
por: Quenum, Akouavi Julite I., et al.
Publicado: (2021)

NLRC5 elicits antitumor immunity by enhancing processing and presentation of tumor antigens to CD8(+) T lymphocytes
por: Rodriguez, Galaxia M., et al.
Publicado: (2016)

NLRC5 Functions beyond MHC I Regulation—What Do We Know So Far?
por: Benkő, Szilvia, et al.
Publicado: (2017)

CIITA and Its Dual Roles in MHC Gene Transcription
por: Devaiah, Ballachanda N., et al.
Publicado: (2013)

SIRT1 links CIITA deacetylation to MHC II activation
por: Wu, Xiaoyan, et al.
Publicado: (2011)

NLRC5, at the Heart of Antigen Presentation
por: Neerincx, Andreas, et al.
Publicado: (2013)

The GIMAP Family Proteins: An Incomplete Puzzle
por: Limoges, Marc-André, et al.
Publicado: (2021)

GTPase of the Immune-Associated Nucleotide Protein 5 Regulates the Lysosomal Calcium Compartment in T Lymphocytes
por: Serrano, Daniel, et al.
Publicado: (2017)

Hepatic stellate cell-intrinsic role of SOCS1 in controlling hepatic fibrogenic response and the pro-inflammatory macrophage compartment during liver fibrosis
por: Kandhi, Rajani, et al.
Publicado: (2023)

GIMAP5 Deficiency Is Associated with Increased AKT Activity in T Lymphocytes
por: Chen, Xi-Lin, et al.
Publicado: (2015)

ADE and hyperinflammation in SARS-CoV2 infection- comparison with dengue hemorrhagic fever and feline infectious peritonitis
por: Cloutier, Maryse, et al.
Publicado: (2020)

NLRC5 affects diet-induced adiposity in female mice and co-regulates peroxisome proliferator-activated receptor PPARγ target genes
por: Bauer, Sarah, et al.
Publicado: (2023)

Protective anti-tumor vaccination against glioblastoma expressing the MHC class II transactivator CIITA
por: Celesti, Fabrizio, et al.
Publicado: (2023)

TCR and IL-7 Signaling Are Altered in the Absence of Functional GTPase of the Immune Associated Nucleotide Binding Protein 5 (GIMAP5)
por: Chen, Xi-Lin, et al.
Publicado: (2016)

IRF-4-Mediated CIITA Transcription Is Blocked by KSHV Encoded LANA to Inhibit MHC II Presentation
por: Cai, Qiliang, et al.
Publicado: (2013)

Role of PU.1 in MHC Class II Expression via CIITA Transcription in Plasmacytoid Dendritic Cells
por: Miura, Ryosuke, et al.
Publicado: (2016)

The MHC-II transactivator CIITA inhibits Tat function and HIV-1 replication in human myeloid cells
por: Forlani, Greta, et al.
Publicado: (2016)

Genomic mapping of the MHC transactivator CIITA using an integrated ChIP-seq and genetical genomics approach
por: Wong, Daniel, et al.
Publicado: (2014)

The MHC Class II transactivator CIITA inhibits the persistent activation of NF-kB by Tax-1
por: Forlani, Greta, et al.
Publicado: (2015)

Protein arginine methyltransferase 1 (PRMT1) represses MHC II transcription in macrophages by methylating CIITA
por: Fan, Zhiwen, et al.
Publicado: (2017)

MHC class II transactivator CIITA induces cell resistance to Ebola virus and SARS-like coronaviruses
por: Bruchez, Anna, et al.
Publicado: (2020)

The MHC Class II Transactivator CIITA: Not (Quite) the Odd-One-Out Anymore among NLR Proteins
por: León Machado, Jorge Alfonso, et al.
Publicado: (2021)

Attenuation of MET-mediated migration and invasion in hepatocellular carcinoma cells by SOCS1
por: Gui, Yirui, et al.
Publicado: (2017)

CIITA promoter I CARD-deficient mice express functional MHC class II genes in myeloid and lymphoid compartments
por: Zinzow-Kramer, Wendy M., et al.
Publicado: (2012)

Degradation, Promoter Recruitment and Transactivation Mediated by the Extreme N-Terminus of MHC Class II Transactivator CIITA Isoform III
por: Beaulieu, Yves B., et al.
Publicado: (2016)

IL-15 Prevents the Development of T-ALL from Aberrant Thymocytes with Impaired DNA Repair Functions and Increased NOTCH1 Activation
por: Nandi, Madhuparna, et al.
Publicado: (2023)

The MHC-II transactivator CIITA, a viral restriction factor inhibiting the replication of Human T-Cell Lymphotropic Virus Type 1
por: Tosi, Giovanna, et al.
Publicado: (2011)

The MHC Class II transactivator CIITA inhibits Tax-1-mediated HTLV-1 expression and NF-kB activation
por: Abdallah, Rawan, et al.
Publicado: (2014)

Fowlpoxvirus recombinants coding for the CIITA gene increase the expression of endogenous MHC-II and Fowlpox Gag/Pro and Env SIV transgenes
por: Bissa, Massimiliano, et al.
Publicado: (2018)

FBXO11 constitutes a major negative regulator of MHC class II through ubiquitin-dependent proteasomal degradation of CIITA
por: Kasuga, Yusuke, et al.
Publicado: (2023)

Inflammatory Cytokine Profiles in Visceral and Subcutaneous Adipose Tissues of Obese Patients Undergoing Bariatric Surgery Reveal Lack of Correlation With Obesity or Diabetes
por: Rakotoarivelo, Volatiana, et al.
Publicado: (2018)

Corrigendum to “Inflammatory cytokine profiles in visceral and subcutaneous adipose tissues of obese patients undergoing bariatric surgery reveal lack of correlation with obesity or diabetes” EBioMedicine 30C (2018) 237–247
por: Rakotoarivelo, Volatiana, et al.
Publicado: (2018)

Expression of SOCS1 and the downstream targets of its putative tumor suppressor functions in prostate cancer
por: Chevrier, Martin, et al.
Publicado: (2017)

Editorial: Mesenchymal and immune cell crosstalk in fibrotic diseases
por: Asahina, Kinji, et al.
Publicado: (2023)

Interferon Regulatory Factors 1 and 2 Play Different Roles in MHC II Expression Mediated by CIITA in Grass Carp, Ctenopharyngodon idella
por: Lu, Xiao-Bing, et al.
Publicado: (2019)

Effect of Vitamin D on Experimental Autoimmune Neuroinflammation Is Dependent on Haplotypes Comprising Naturally Occurring Allelic Variants of CIITA (Mhc2ta)
por: Hochmeister, Sonja, et al.
Publicado: (2020)

Roles for common MLL/COMPASS subunits and the 19S proteasome in regulating CIITA pIV and MHC class II gene expression and promoter methylation
por: Koues, Olivia I, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_pdo5q1uo2prq5samf98po32rf7