Ursodeoxycholic Acid Binds PERK and Ameliorates Neurite Atrophy in a Cellular Model of GM2 Gangliosidosis

The Unfolded protein response (UPR), triggered by stress in the endoplasmic reticulum (ER), is a key driver of neurodegenerative diseases. GM2 gangliosidosis, which includes Tay-Sachs and Sandhoff disease, is caused by an accumulation of GM2, mainly in the brain, that leads to progressive neurodegen...

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Detalles Bibliográficos
Autores principales: Morales, Carolina, Fernandez, Macarena, Ferrer, Rodrigo, Raimunda, Daniel, Carrer, Dolores C., Bollo, Mariana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138647/
https://www.ncbi.nlm.nih.gov/pubmed/37108372
http://dx.doi.org/10.3390/ijms24087209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138647/
https://www.ncbi.nlm.nih.gov/pubmed/37108372
http://dx.doi.org/10.3390/ijms24087209

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