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Ursodeoxycholic Acid Binds PERK and Ameliorates Neurite Atrophy in a Cellular Model of GM2 Gangliosidosis

The Unfolded protein response (UPR), triggered by stress in the endoplasmic reticulum (ER), is a key driver of neurodegenerative diseases. GM2 gangliosidosis, which includes Tay-Sachs and Sandhoff disease, is caused by an accumulation of GM2, mainly in the brain, that leads to progressive neurodegen...

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Detalles Bibliográficos
Autores principales:	Morales, Carolina, Fernandez, Macarena, Ferrer, Rodrigo, Raimunda, Daniel, Carrer, Dolores C., Bollo, Mariana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138647/ https://www.ncbi.nlm.nih.gov/pubmed/37108372 http://dx.doi.org/10.3390/ijms24087209

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