Synergistic Action of MCL-1 Inhibitor with BCL-2/BCL-XL or MAPK Pathway Inhibitors Enhances Acute Myeloid Leukemia Cell Apoptosis and Differentiation

Acute myeloid leukemia (AML) is a hematological malignancy characterized by excessive proliferation of abnormal myeloid precursors accompanied by a differentiation block and inhibition of apoptosis. Increased expression of an anti-apoptotic MCL-1 protein was shown to be critical for the sustained su...

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Detalles Bibliográficos
Autores principales: Opydo, Małgorzata, Mlyczyńska, Anna, Mlyczyńska, Ewa, Rak, Agnieszka, Kolaczkowska, Elzbieta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138770/
https://www.ncbi.nlm.nih.gov/pubmed/37108344
http://dx.doi.org/10.3390/ijms24087180

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138770/
https://www.ncbi.nlm.nih.gov/pubmed/37108344
http://dx.doi.org/10.3390/ijms24087180

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