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Sequence similarity governs generalizability of de novo deep learning models for RNA secondary structure prediction

Making no use of physical laws or co-evolutionary information, de novo deep learning (DL) models for RNA secondary structure prediction have achieved far superior performances than traditional algorithms. However, their statistical underpinning raises the crucial question of generalizability. We pre...

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Detalles Bibliográficos
Autor principal: Qiu, Xiangyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10138783/
https://www.ncbi.nlm.nih.gov/pubmed/37068100
http://dx.doi.org/10.1371/journal.pcbi.1011047