Cargando…

Glucocorticoid Receptor and β-Catenin Interact in Prostate Cancer Cells and Their Co-Inhibition Attenuates Tumorsphere Formation, Stemness, and Docetaxel Resistance

Therapy resistance hinders the efficacy of anti-androgen therapies and taxane-based chemotherapy for advanced prostate cancer (PCa). Glucocorticoid receptor (GR) signaling mediates resistance to androgen receptor signaling inhibitors (ARSI) and has also been recently implicated in PCa resistance to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Martinez, Shannalee R., Elix, Catherine C., Ochoa, Pedro T., Sanchez-Hernandez, Evelyn S., Alkashgari, Hossam R., Ortiz-Hernandez, Greisha L., Zhang, Lubo, Casiano, Carlos A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139020/ https://www.ncbi.nlm.nih.gov/pubmed/37108293 http://dx.doi.org/10.3390/ijms24087130

Ejemplares similares

The LEDGF/p75 Integrase Binding Domain Interactome Contributes to the Survival, Clonogenicity, and Tumorsphere Formation of Docetaxel-Resistant Prostate Cancer Cells
por: Ortiz-Hernandez, Greisha L., et al.
Publicado: (2021)

Glucocorticoid Receptor Regulates and Interacts with LEDGF/p75 to Promote Docetaxel Resistance in Prostate Cancer Cells
por: Sanchez-Hernandez, Evelyn S., et al.
Publicado: (2023)

Glucocorticoids Induce Stress Oncoproteins Associated with Therapy-Resistance in African American and European American Prostate Cancer Cells
por: Woods-Burnham, Leanne, et al.
Publicado: (2018)

Twenty years of research on the DFS70/LEDGF autoantibody-autoantigen system: many lessons learned but still many questions
por: Ortiz-Hernandez, Greisha L., et al.
Publicado: (2020)

MicroRNA-210 suppresses glucocorticoid receptor expression in response to hypoxia in fetal rat cardiomyocytes
por: Martinez, Shannalee R., et al.
Publicado: (2017)

The Nuclear Dense Fine Speckled (DFS) Immunofluorescence Pattern: Not All Roads Lead to DFS70/LEDGFp75
por: Sanchez-Hernandez, Evelyn S., et al.
Publicado: (2023)

TSLP as a Potential Therapy in the Treatment of CRLF2 B Cell Acute Lymphoblastic Leukemia
por: Alkashgari, Hossam R., et al.
Publicado: (2022)

THU502 CYR61, A Member Of The CCN Protein Family, Regulates IGF1 In Metastatic Prostate Cancer
por: Ortiz Hernandez, Greisha L, et al.
Publicado: (2023)

RNA sequencing reveals upregulation of a transcriptomic program associated with stemness in metastatic prostate cancer cells selected for taxane resistance
por: Cajigas-Du Ross, Christina K., et al.
Publicado: (2018)

Alpha-Enolase: Emerging Tumor-Associated Antigen, Cancer Biomarker, and Oncotherapeutic Target
por: Almaguel, Frankis A., et al.
Publicado: (2021)

Glucocorticoid receptor antagonism reverts docetaxel resistance in human prostate cancer
por: Kroon, Jan, et al.
Publicado: (2016)

Understanding the influence of substrate when growing tumorspheres
por: Benítez, Lucía, et al.
Publicado: (2021)

Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75
por: Mediavilla-Varela, Melanie, et al.
Publicado: (2009)

Inhibitory Effects of Peptide Lunasin in Colorectal Cancer HCT-116 Cells and Their Tumorsphere-Derived Subpopulation
por: Fernández-Tomé, Samuel, et al.
Publicado: (2020)

Success of tumorsphere isolation from WHO grade IV gliomas does not correlate with the weight of fresh tumor specimens: an immunohistochemical characterization of tumorsphere differentiation
por: Sung, Kyoung Su, et al.
Publicado: (2016)

Formation of Tumorspheres with Increased Stemness without External Mitogens in a Lung Cancer Model
por: Yakisich, Juan Sebastian, et al.
Publicado: (2016)

Combined effects of niclosamide and temozolomide against human glioblastoma tumorspheres
por: Oh, Hyeong-Cheol, et al.
Publicado: (2020)

Pharmacological targeting of the novel β-catenin chromatin-associated kinase p38α in colorectal cancer stem cell tumorspheres and organoids
por: Lepore Signorile, Martina, et al.
Publicado: (2021)

LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 in Prostate Cancer
por: Basu, Anamika, et al.
Publicado: (2016)

Monoamine oxidase-A activity is required for clonal tumorsphere formation by human breast tumor cells
por: Gwynne, William D., et al.
Publicado: (2019)

Response of Estrogen Receptor-Positive Breast Cancer Tumorspheres to Antiestrogen Treatments
por: Ao, Ada, et al.
Publicado: (2011)

Tumorspheres but Not Adherent Cells Derived from Retinoblastoma Tumors Are of Malignant Origin
por: Bond, Wesley S., et al.
Publicado: (2013)

The chemomodulatory effects of glufosfamide on docetaxel cytotoxicity in prostate cancer cells
por: Attia, Reem T., et al.
Publicado: (2016)

Tumorsphere as an effective in vitro platform for screening anti-cancer stem cell drugs
por: Lee, Che-Hsin, et al.
Publicado: (2015)

Profiling Anti-Apoptotic BCL-xL Protein Expression in Glioblastoma Tumorspheres
por: Fanfone, Deborah, et al.
Publicado: (2020)

Co-expression of cancer driver genes: IDH-wildtype glioblastoma-derived tumorspheres
por: Yoon, Seon-Jin, et al.
Publicado: (2020)

The aqueous extract of brucea javanica reduces tumorigenicity of human lung cancer tumorspheres
por: Kim, Seung-Hun, et al.
Publicado: (2021)

Adipose-derived mesenchymal stem cells exhibit tumor tropism and promote tumorsphere formation of breast cancer cells
por: Chen, Yanqing, et al.
Publicado: (2019)

Characterization of a human tumorsphere glioma orthotopic model using magnetic resonance imaging
por: Wong, Kelvin, et al.
Publicado: (2011)

Effect of the JAK2/STAT3 inhibitor SAR317461 on human glioblastoma tumorspheres
por: Mukthavaram, Rajesh, et al.
Publicado: (2015)

A lignan from Alnus japonica inhibits glioblastoma tumorspheres by suppression of FOXM1
por: Shim, Jin-Kyoung, et al.
Publicado: (2022)

SOX2OT lncRNA Inhibition Suppresses the Stemness Characteristics of Esophageal Tumorspheres
por: Haghi, Boshra, et al.
Publicado: (2022)

The Culture of Cancer Cell Lines as Tumorspheres Does Not Systematically Result in Cancer Stem Cell Enrichment
por: Calvet, Christophe Y., et al.
Publicado: (2014)

Transcriptional Profiling of Tumorspheres Reveals TRPM4 as a Novel Stemness Regulator in Breast Cancer
por: Verigos, John, et al.
Publicado: (2021)

Targeting the stress oncoprotein LEDGF/p75 to sensitize chemoresistant prostate cancer cells to taxanes
por: Ríos-Colón, Leslimar, et al.
Publicado: (2017)

RUNX2 and TAZ-dependent signaling pathways regulate soluble E-Cadherin levels and tumorsphere formation in breast cancer cells
por: Brusgard, Jessica L., et al.
Publicado: (2015)

Effect of CD44 Binding Peptide Conjugated to an Engineered Inert Matrix on Maintenance of Breast Cancer Stem Cells and Tumorsphere Formation
por: Yang, Xiaoming, et al.
Publicado: (2013)

Undifferentiated prostate cancer treated with docetaxel
por: Kobayashi, Masaki, et al.
Publicado: (2020)

Docetaxel Resistance in Castration-Resistant Prostate Cancer: Transcriptomic Determinants and the Effect of Inhibiting Wnt/β-Catenin Signaling by XAV939
por: Pudova, Elena, et al.
Publicado: (2022)

The number of tumorspheres cultured from peripheral blood is a predictor for presence of metastasis in patients with breast cancer
por: Pizon, Monika, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_bktvdafdp978vls93ltm19c37a