Carborane-Containing Hydroxamate MMP Ligands for the Treatment of Tumors Using Boron Neutron Capture Therapy (BNCT): Efficacy without Tumor Cell Entry

New carborane-bearing hydroxamate matrix metalloproteinase (MMP) ligands have been synthesized for boron neutron capture therapy (BNCT) with nanomolar potency against MMP-2, -9 and -13. New analogs are based on MMP inhibitor CGS-23023A, and two previously reported MMP ligands 1 (B1) and 2 (B2) were...

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Detalles Bibliográficos
Autores principales: Flieger, Sebastian, Takagaki, Mao, Kondo, Natsuko, Lutz, Marlon R., Gupta, Yash, Ueda, Hiroki, Sakurai, Yoshinori, Moran, Graham, Kempaiah, Prakasha, Hosmane, Narayan, Suzuki, Minoru, Becker, Daniel P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139035/
https://www.ncbi.nlm.nih.gov/pubmed/37108137
http://dx.doi.org/10.3390/ijms24086973

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139035/
https://www.ncbi.nlm.nih.gov/pubmed/37108137
http://dx.doi.org/10.3390/ijms24086973

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