Novel Functionalized Spiro [Indoline-3,5′-pyrroline]-2,2′dione Derivatives: Synthesis, Characterization, Drug-Likeness, ADME, and Anticancer Potential

A highly stereo-selective, one-pot, multicomponent method was chosen to synthesize the novel functionalized 1, 3-cycloaddition spirooxindoles (SOXs) (4a–4h). Synthesized SOXs were analyzed for their drug-likeness and ADME parameters and screened for their anticancer activity. Our molecular docking a...

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Detalles Bibliográficos
Autores principales: Asif, Mohd, Alvi, Sahir Sultan, Azaz, Tazeen, Khan, Abdul Rahman, Tiwari, Bhoopendra, Hafeez, Bilal Bin, Nasibullah, Malik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139052/
https://www.ncbi.nlm.nih.gov/pubmed/37108498
http://dx.doi.org/10.3390/ijms24087336

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139052/
https://www.ncbi.nlm.nih.gov/pubmed/37108498
http://dx.doi.org/10.3390/ijms24087336

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