Identification of Gene Expression Signatures for Phenotype-Specific Drug Targeting of Cardiac Fibrosis

We have designed translational animal models to investigate cardiac profibrotic gene signatures. Domestic pigs were treated with cardiotoxic drugs (doxorubicin, DOX, n = 5 or Myocet(®), MYO, n = 5) to induce replacement fibrosis via cardiotoxicity. Reactive interstitial fibrosis was triggered by LV...

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Detalles Bibliográficos
Autores principales: Lukovic, Dominika, Hasimbegovic, Ena, Winkler, Johannes, Mester-Tonczar, Julia, Müller-Zlabinger, Katrin, Han, Emilie, Spannbauer, Andreas, Traxler-Weidenauer, Denise, Bergler-Klein, Jutta, Pavo, Noemi, Goliasch, Georg, Batkai, Sandor, Thum, Thomas, Zannad, Faiez, Gyöngyösi, Mariann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139067/
https://www.ncbi.nlm.nih.gov/pubmed/37108624
http://dx.doi.org/10.3390/ijms24087461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139067/
https://www.ncbi.nlm.nih.gov/pubmed/37108624
http://dx.doi.org/10.3390/ijms24087461

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