GSK-3β Allosteric Inhibition: A Dead End or a New Pharmacological Frontier?

Most kinase inhibitors are designed to bind to highly homologous ATP-binding sites, which leads to promiscuity and possible off-target effects. Allostery is an alternative approach to pursuing selectivity. However, allostery is difficult to exploit due to the wide variety of underlying mechanisms an...

Descripción completa

Detalles Bibliográficos
Autores principales: Balboni, Beatrice, Masi, Mirco, Rocchia, Walter, Girotto, Stefania, Cavalli, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139115/
https://www.ncbi.nlm.nih.gov/pubmed/37108703
http://dx.doi.org/10.3390/ijms24087541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139115/
https://www.ncbi.nlm.nih.gov/pubmed/37108703
http://dx.doi.org/10.3390/ijms24087541

Ejemplares similares