Small-Molecule Cyclophilin Inhibitors Potently Reduce Platelet Procoagulant Activity

Procoagulant platelets are associated with an increased risk for thrombosis. Procoagulant platelet formation is mediated via Cyclophilin D (CypD) mediated opening of the mitochondrial permeability transition pore. Inhibiting CypD activity could therefore be an interesting approach to limiting thromb...

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Detalles Bibliográficos
Autores principales: Van Bael, Jens, Vandenbulcke, Aline, Ahmed-Belkacem, Abdelhakim, Guichou, Jean-François, Pawlotsky, Jean-Michel, Samyn, Jelle, Barendrecht, Arjan D., Maas, Coen, De Meyer, Simon F., Vanhoorelbeke, Karen, Tersteeg, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139176/
https://www.ncbi.nlm.nih.gov/pubmed/37108326
http://dx.doi.org/10.3390/ijms24087163

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139176/
https://www.ncbi.nlm.nih.gov/pubmed/37108326
http://dx.doi.org/10.3390/ijms24087163

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