FTY720-P, a Biased S1PR Ligand, Increases Mitochondrial Function through STAT3 Activation in Cardiac Cells

FTY720 is an FDA-approved sphingosine derivative drug for the treatment of multiple sclerosis. This compound blocks lymphocyte egress from lymphoid organs and autoimmunity through sphingosine 1-phosphate (S1P) receptor blockage. Drug repurposing of FTY720 has revealed improvements in glucose metabol...

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Detalles Bibliográficos
Autores principales: Muñoz, Juan Pablo, Sànchez-Fernàndez-de-Landa, Paula, Diarte-Añazco, Elena María Goretti, Zorzano, Antonio, Blanco-Vaca, Francisco, Julve, Josep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139230/
https://www.ncbi.nlm.nih.gov/pubmed/37108539
http://dx.doi.org/10.3390/ijms24087374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139230/
https://www.ncbi.nlm.nih.gov/pubmed/37108539
http://dx.doi.org/10.3390/ijms24087374

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