Factor VIII mutated with Lys1813Ala within the factor IXa-binding region enhances intrinsic coagulation potential

Factor VIII (FVIII) functions as a cofactor of FIXa for FX activation in the intrinsic tenase complex. The 1811-1818 region in the FVIII A3 domain was observed to contribute to FIXa binding, and the K1813A/K1818A mutant increased the binding affinity for FIXa. The current study aims to identify muta...

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Detalles Bibliográficos
Autores principales: Nakajima, Yuto, Takeyama, Masahiro, Oda, Akihisa, Shimonishi, Naruto, Nogami, Keiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139940/
https://www.ncbi.nlm.nih.gov/pubmed/36322904
http://dx.doi.org/10.1182/bloodadvances.2022008187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139940/
https://www.ncbi.nlm.nih.gov/pubmed/36322904
http://dx.doi.org/10.1182/bloodadvances.2022008187

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