Spatially coordinated collective phosphorylation filters spatiotemporal noises for precise circadian timekeeping

The circadian (∼24h) clock is based on a negative-feedback loop centered around the PERIOD protein (PER), translated in the cytoplasm and then enters the nucleus to repress its own transcription at the right time of day. Such precise nucleus entry is mysterious because thousands of PER molecules tra...

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Detalles Bibliográficos
Autores principales: Chae, Seok Joo, Kim, Dae Wook, Lee, Seunggyu, Kim, Jae Kyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139964/
https://www.ncbi.nlm.nih.gov/pubmed/37123226
http://dx.doi.org/10.1016/j.isci.2023.106554

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139964/
https://www.ncbi.nlm.nih.gov/pubmed/37123226
http://dx.doi.org/10.1016/j.isci.2023.106554

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