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Spatially coordinated collective phosphorylation filters spatiotemporal noises for precise circadian timekeeping
The circadian (∼24h) clock is based on a negative-feedback loop centered around the PERIOD protein (PER), translated in the cytoplasm and then enters the nucleus to repress its own transcription at the right time of day. Such precise nucleus entry is mysterious because thousands of PER molecules tra...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10139964/ https://www.ncbi.nlm.nih.gov/pubmed/37123226 http://dx.doi.org/10.1016/j.isci.2023.106554 |