Cryo-EM reveals the membrane-binding phenomenon of EspB, a virulence factor of the mycobacterial type VII secretion system

Mycobacterium tuberculosis (Mtb) utilizes sophisticated machinery called the type VII secretion system to translocate virulence factors across its complex lipid membrane. EspB, a ∼36 kDa secreted substrate of the ESX-1 apparatus, was shown to cause ESAT-6–independent host cell death. Despite the cur...

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Detalles Bibliográficos
Autores principales: Sengupta, Nayanika, Padmanaban, Surekha, Dutta, Somnath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140165/
https://www.ncbi.nlm.nih.gov/pubmed/36889587
http://dx.doi.org/10.1016/j.jbc.2023.104589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140165/
https://www.ncbi.nlm.nih.gov/pubmed/36889587
http://dx.doi.org/10.1016/j.jbc.2023.104589

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