A bivalent β-carboline derivative inhibits macropinocytosis-dependent entry of pseudorabies virus by targeting the kinase DYRK1A

Pseudorabies virus (PRV) has become a “new life-threatening zoonosis” since the human-originated PRV strain was first isolated in 2020. To identify novel anti-PRV agents, we screened a total of 107 β-carboline derivatives and found 20 compounds displaying antiviral activity against PRV. Among them,...

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Detalles Bibliográficos
Autores principales: Wang, Chongyang, Hu, Ruochen, Wang, Ting, Duan, Liuyuan, Hou, Qili, Wang, Junru, Yang, Zengqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140166/
https://www.ncbi.nlm.nih.gov/pubmed/36918100
http://dx.doi.org/10.1016/j.jbc.2023.104605

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140166/
https://www.ncbi.nlm.nih.gov/pubmed/36918100
http://dx.doi.org/10.1016/j.jbc.2023.104605

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