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Structures of calmodulin–melittin complexes show multiple binding modes lacking classical anchoring interactions

Calmodulin (CaM) is a Ca(2+) sensor protein found in all eukaryotic cells that regulates a large number of target proteins in a Ca(2+) concentration-dependent manner. As a transient-type hub protein, it recognizes linear motifs of its targets, though for the Ca(2+)-dependent binding, no consensus se...

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Detalles Bibliográficos
Autores principales: Dürvanger, Zsolt, Juhász, Tünde, Liliom, Károly, Harmat, Veronika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140167/
https://www.ncbi.nlm.nih.gov/pubmed/36906144
http://dx.doi.org/10.1016/j.jbc.2023.104596