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Aβ1-42-containing platelet-derived extracellular vesicle is associated with cognitive decline in Parkinson’s disease

BACKGROUND: Cortical amyloid deposition is a common observation in Parkinson’s disease dementia (PDD) patients. Aβ1-42 is linked to a more rapid progression of dementia. Platelets, which degranulate upon activation, are a primary source of Aβ. It has been repeatedly reported that peripheral extracel...

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Autores principales: Wang, Ziyu, Zheng, Yuanchu, Cai, Huihui, Yang, Chen, Li, Siming, Lv, Hong, Feng, Tao, Yu, Zhenwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140302/
https://www.ncbi.nlm.nih.gov/pubmed/37122378
http://dx.doi.org/10.3389/fnagi.2023.1170663
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author Wang, Ziyu
Zheng, Yuanchu
Cai, Huihui
Yang, Chen
Li, Siming
Lv, Hong
Feng, Tao
Yu, Zhenwei
author_facet Wang, Ziyu
Zheng, Yuanchu
Cai, Huihui
Yang, Chen
Li, Siming
Lv, Hong
Feng, Tao
Yu, Zhenwei
author_sort Wang, Ziyu
collection PubMed
description BACKGROUND: Cortical amyloid deposition is a common observation in Parkinson’s disease dementia (PDD) patients. Aβ1-42 is linked to a more rapid progression of dementia. Platelets, which degranulate upon activation, are a primary source of Aβ. It has been repeatedly reported that peripheral extracellular vesicles (EVs) can partially reach the central nervous system. Thus, we speculate that activated platelet-derived Aβ1-42-containing EVs (PEV-Aβ1-42) play a crucial role in the cognitive decline of PD patients. METHODS: The study included 189 participants: 66 with non-dementia PD, 73 with PDD, and 50 healthy controls. All participants underwent blood collection and clinical assessments. Twenty PD patients underwent re-examination and repeated blood collection 14 months later. A nano-scale flow cytometry assay was used to detect PEVs and PEV-Aβ1-42 using fluorescence-labeled CD62P and Aβ1-42 antibodies. RESULTS: Parkinson’s disease dementia patients had higher PEV-Aβ1-42 concentrations than healthy controls (p = 0.028). The ratio of PEV-Aβ1-42 to PEV was significantly higher in PDD patients compared to those in non-dementia PD and healthy controls (p(PD-ND) < 0.001, p(HC) = 0.041). The PEV-Aβ1-42/PEV ratio appears to influence the odds of developing dementia (OR = 1.76, p < 0.001). The change in the PEV-Aβ1-42/PEV ratio was also correlated with cognitive decline over 14 months (r = −0.447, p < 0.05). CONCLUSION: The plasma PEV-Aβ1-42/PEV ratio may serve as a diagnostic and prognostic biomarker for PDD patients.
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spelling pubmed-101403022023-04-29 Aβ1-42-containing platelet-derived extracellular vesicle is associated with cognitive decline in Parkinson’s disease Wang, Ziyu Zheng, Yuanchu Cai, Huihui Yang, Chen Li, Siming Lv, Hong Feng, Tao Yu, Zhenwei Front Aging Neurosci Aging Neuroscience BACKGROUND: Cortical amyloid deposition is a common observation in Parkinson’s disease dementia (PDD) patients. Aβ1-42 is linked to a more rapid progression of dementia. Platelets, which degranulate upon activation, are a primary source of Aβ. It has been repeatedly reported that peripheral extracellular vesicles (EVs) can partially reach the central nervous system. Thus, we speculate that activated platelet-derived Aβ1-42-containing EVs (PEV-Aβ1-42) play a crucial role in the cognitive decline of PD patients. METHODS: The study included 189 participants: 66 with non-dementia PD, 73 with PDD, and 50 healthy controls. All participants underwent blood collection and clinical assessments. Twenty PD patients underwent re-examination and repeated blood collection 14 months later. A nano-scale flow cytometry assay was used to detect PEVs and PEV-Aβ1-42 using fluorescence-labeled CD62P and Aβ1-42 antibodies. RESULTS: Parkinson’s disease dementia patients had higher PEV-Aβ1-42 concentrations than healthy controls (p = 0.028). The ratio of PEV-Aβ1-42 to PEV was significantly higher in PDD patients compared to those in non-dementia PD and healthy controls (p(PD-ND) < 0.001, p(HC) = 0.041). The PEV-Aβ1-42/PEV ratio appears to influence the odds of developing dementia (OR = 1.76, p < 0.001). The change in the PEV-Aβ1-42/PEV ratio was also correlated with cognitive decline over 14 months (r = −0.447, p < 0.05). CONCLUSION: The plasma PEV-Aβ1-42/PEV ratio may serve as a diagnostic and prognostic biomarker for PDD patients. Frontiers Media S.A. 2023-04-14 /pmc/articles/PMC10140302/ /pubmed/37122378 http://dx.doi.org/10.3389/fnagi.2023.1170663 Text en Copyright © 2023 Wang, Zheng, Cai, Yang, Li, Lv, Feng and Yu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging Neuroscience
Wang, Ziyu
Zheng, Yuanchu
Cai, Huihui
Yang, Chen
Li, Siming
Lv, Hong
Feng, Tao
Yu, Zhenwei
Aβ1-42-containing platelet-derived extracellular vesicle is associated with cognitive decline in Parkinson’s disease
title Aβ1-42-containing platelet-derived extracellular vesicle is associated with cognitive decline in Parkinson’s disease
title_full Aβ1-42-containing platelet-derived extracellular vesicle is associated with cognitive decline in Parkinson’s disease
title_fullStr Aβ1-42-containing platelet-derived extracellular vesicle is associated with cognitive decline in Parkinson’s disease
title_full_unstemmed Aβ1-42-containing platelet-derived extracellular vesicle is associated with cognitive decline in Parkinson’s disease
title_short Aβ1-42-containing platelet-derived extracellular vesicle is associated with cognitive decline in Parkinson’s disease
title_sort aβ1-42-containing platelet-derived extracellular vesicle is associated with cognitive decline in parkinson’s disease
topic Aging Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10140302/
https://www.ncbi.nlm.nih.gov/pubmed/37122378
http://dx.doi.org/10.3389/fnagi.2023.1170663
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